Table 2.
Prevalence, grade and duration of the adverse events.
| Adverse Event | AE Presence n (%) |
Grade 1 n (%) |
Grade 2 n (%) |
Grade 3 n (%) |
Duration of the AE (Months) Mean ± SD Median (Range) |
Duration of the G Max AE (Months) Mean ± SD Median (Range) |
|---|---|---|---|---|---|---|
| Diarrhea | 14 (77.8) | 9 (64.3) | 3 (21.4) | 2 (14.3) | 5.8 ± 3.7 5.2 (0.3–12) |
4.7 ± 4.4 4.2 (0.06–12) |
| Nausea, vomiting and epigastric pain | 12 (66.7) | 9 (75) | 3 (25) | 0 (0) | 4.5 ± 4.8 2.5 (0.03–12) |
4.2 ± 4.8 1.9 (0.03–11.9) |
| Oral mucositis and xerostomia | 15 (83.4) | 11 (73.4) | 3 (20) | 1 (6.6) | 7.5 ± 4.4 8.6 (1–12) |
6.0 ± 4.5 4.2 (1–12) |
| Hypertension | 13 (72.3) | 2 (15.3) | 7 (53.8) | 4 (30.9) | 9.2 ± 4.2 30 (2.6–12) |
9.1 ± 3.9 30 (2.6–12) |
| Proteinuria | 5 (29.4) | 2 (40) | 1 (20) | 2 (40) | 4.9 ± 4.3 2 (1.3–9.7) |
1.24 ± 0.7 1.3 (0.33–2) |
| Asthenia | 13 (76.5) | 7 (53.8) | 4 (30.8) | 2 (15.4) | 7.6 ± 4.3 7.3 (1.4–12) |
5.5 ± 4.9 4.6 (0.13–12) |
| Anorexia | 13 (76.5) | 7 (53.8) | 2 (15.4) | 4 (30.8) | 7.9 ± 4.7 10.3 (0.6–12) |
5.6 ± 5.1 3.8 (0.13–12) |
| Hand-foot syndrome | 9 (50) | 4 (44.4) | 5 (55.6) | 0 (0) | 6.6 ± 4.3 5.8 (1.3–12) |
6.0 ± 4.3 4.5 (1.3–12) |
| Weight loss | 11 (61.1) | 4 (36.4) | 5 (45.4) | 2 (18.2) | * | * |
* Mean time to reach the minimum weight 10.3 ± 2.6 months, median 11.6 (range 4.96–12.3) months.