Table 4.
p value by chi-squared test at genotype and allele level for the presence/absence and the grade of diarrhea. Correlation between diarrhea side effect and polymorphisms linked to MKI metabolism.
| Presence/Absence of Diarrhoea | Grade of Diarrhoea | ||||
|---|---|---|---|---|---|
| Gene | Polymorphism |
p Value (Genotype Level) |
p Value (Allele Level) |
p Value (Genotype Level) |
p Value (Allele Level) |
| CYP3A4 | rs2687116 | 0.42 | 0.43 | 0.26 | 0.29 |
| CYP3A4 | rs2242480 | 0.64 | 0.3 | 0.03 * | 0.04 * |
| CYP3A5 | rs776746 | 0.64 | 0.33 | 0.03 * | 0.04 * |
| ABCB1 | rs2032582 | 0.27 | 0.72 | 0.72 | 0.71 |
| ABCB1 | rs1045642 | 0.28 | 0.17 | 0.37 | 0.67 |
| ABCB1 | rs2235048 | 0.22 | 0.12 | 0.11 | 0.24 |
| ABCG2 | rs2231142 | 0.08 | 0.89 | 0.4 | 0.45 |
* statistically significant.