Table 6.
p value by chi-squared test at genotype and allele level for the presence/absence and the grade of nausea, vomiting and epigastric pain. Correlation between nausea, vomiting and epigastric pain side effects and polymorphisms linked to MKI metabolism.
| Presence/Absence of Nausea, Vomiting and Epigastric Pain | Grade of Nausea, Vomiting and Epigastric Pain | ||||
|---|---|---|---|---|---|
| Gene | Polymorphism |
p Value (Genotype Level) |
p Value (Allele Level) |
p Value (Genotype Level) |
p Value (Allele Level) |
| CYP3A4 | rs2687116 | 0.28 | 0.29 | 0.37 | 0.42 |
| CYP3A4 | rs2242480 | 0.56 | 0.19 | 0.67 | 0.3 |
| CYP3A5 | rs776746 | 0.56 | 0.19 | 0.67 | 0.28 |
| ABCB1 | rs2032582 | 0.37 | 0.71 | 0.13 | 0.16 |
| ABCB1 | rs1045642 | 0.17 | 0.18 | 0.08 | 0.1 |
| ABCB1 | rs2235048 | 0.1 | 0.12 | 0.06 | 0.019 * |
| ABCG2 | rs2231142 | 0.68 | 0.67 | 0.7 | 0.72 |
* statistically significant.