Table 8.
p value by chi-squared test at genotype and allele level for the presence/absence and grade of hypertension. Correlation between hypertension side effect and polymorphisms linked to MKI metabolism.
| Presence/Absence of Hypertension | Grade of Hypertension | ||||
|---|---|---|---|---|---|
| Gene | Polymorphism |
p Value (Genotype Level) |
p Value (Allele Level) |
p Value (Genotype Level) |
p Value (Allele Level) |
| CYP3A4 | rs2687116 | 0.35 | 0.38 | 0.68 | 0.64 |
| CYP3A4 | rs2242480 | 0.02 * | 0.001 * | 0.54 | 0.39 |
| CYP3A5 | rs776746 | 0.02 * | 0.0013 * | 0.91 | 0.8 |
| ABCB1 | rs2032582 | 0.61 | 0.76 | 0.5 | 0.47 |
| ABCB1 | rs1045642 | 0.27 | 0.74 | 0.08 | 0.25 |
| ABCB1 | rs2235048 | 0.27 | 0.74 | 0.09 | 0.25 |
| ABCG2 | rs2231142 | 0.65 | 0.7 | 0.27 | 0.28 |
* statistically significant.