Table 9.
p value by chi-squared test at genotype and allele level for the presence/absence and grade of asthenia. Correlation between asthenia side effect and polymorphisms linked to MKI metabolism.
| Presence/Absence of Asthenia | Grade of Asthenia | ||||
|---|---|---|---|---|---|
| Gene | Polymorphism |
p Value (Genotype Level) |
p Value (Allele Level) |
p Value (Genotype Level) |
p Value (Allele Level) |
| CYP3A4 | rs2687116 | 0.4 | 0.9 | 0.72 | 0.74 |
| CYP3A4 | rs2242480 | 0.7 | 0.56 | 0.08 | 0.02 * |
| CYP3A5 | rs776746 | 0.7 | 0.56 | 0.08 | 0.022 * |
| ABCB1 | rs2032582 | 0.24 | 0.4 | 0.14 | 0.11 |
| ABCB1 | rs1045642 | 0.64 | 0.4 * | 0.28 | 0.49 |
| ABCB1 | rs2235048 | 0.64 | 0.82 | 0.28 | 0.49 |
| ABCG2 | rs2231142 | 0.28 | 0.9 | 0.017 * | 0.028 * |
* statistically significant.