Table 10.
p value by chi-squared test at genotype and allele level for weight loss. Correlation between weight loss side effect and polymorphisms linked to MKI metabolism.
| Presence/Absence of Weight Loss | Grade of Weight Loss | ||||
|---|---|---|---|---|---|
| Gene | Polymorphism |
p Value (Genotype Level) |
p Value (Allele Level) |
p Value (Genotype Level) |
p Value (Allele Level) |
| CYP3A4 | rs2687116 | 0.5 | 0.49 | 0.28 | 0.2 |
| CYP3A4 | rs2242480 | 0.79 | 0.39 | 0.17 | 0.15 |
| CYP3A5 | rs776746 | 0.79 | 0.39 | 0.17 | 0.15 |
| ABCB1 | rs2032582 | 0.3 | 0.18 | 0.18 | 0.94 |
| ABCB1 | rs1045642 | 0.003 * | 0.014 * | 0.8 | 0.49 |
| ABCB1 | rs2235048 | 0.003 * | 0.02 * | 0.8 | 0.29 |
| ABCG2 | rs2231142 | 0.61 | 0.22 | 0.06 | 0.14 |
* statistically significant.