Table 11.
p value by chi-squared test at genotype and allele level for best response and interval to reach the best response. Correlation between response to Lenvatinib and polymorphisms linked to MKI metabolism.
| Best Response | Time Interval | ||||
|---|---|---|---|---|---|
| Gene | Polymorphism |
p Value (Genotype Level) |
p Value (Allele Level) |
p Value (Genotype Level) |
p Value (Allele Level) |
| CYP3A4 | rs2687116 | 0.14 | 0.97 | 0.17 | 0.26 |
| CYP3A4 | rs2242480 | 0.68 | 0.87 | 0.013 * | <0.0001 * |
| ABCB1 | rs2032582 | 0.24 | 0.57 | 0.14 | 0.6 |
| ABCB1 | rs1045642 | 0.5 | 0.66 | 0.11 | 0.08 |
| ABCB1 | rs2235048 | 0.3 | 0.43 | 0.11 | 0.07 |
| ABCG2 | rs2231142 | 0.13 | 0.31 | 0.5 | 0.57 |
| CYP3A5 | rs776746 | 0.68 | 0.87 | 0.013 * | <0.0001 * |
* statistically significant.