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Systemic beneficial effects of SGLT2 inhibitors that contributes to cardiovascular and renal protection. AMPK, Adenosine Monophosphate Kinase; ATP, Adenosine Triphosphate; EPO, Erythrpoietin; NHE1, Sodium Hydrogen Exchange 1; PCT Proximal Convoluted Tubule; ROS, Reactive Oxygen Species; SGLT2i, Sodium Glucose Transporter 2 inhibitors; SIRT-1 Sirtuin 1; SNS, sympathetic nervous system; TGF, Tubuloglomerular Feedback.
