6. Design features of trials for hypertensive type 2 diabetic participants, by date trial initiated or earliest publication.

Characteristic	UKPDS/HDS	ABCD (2)	Steno‐2	Rachmani 2002	ADDITION‐Europe	ADVANCE/AdRem	DEMAND	BENEDICT	HINTS	J‐DOIT3
Year trial initiated	1987	1991	1992	1995	2001	2002	2002	2003a	2006	2006
Definition of "hypertension", SBP/DBP, mmHg, or otherb	≥ 160/95 or antihypertensive medication	DBP ≥ 90	≥ 160/95 (≥ 135/85)	> 140/90 or antihypertensive medication	> 135/85	> 140/90 or antihypertensive medication	≥ 130/85 or antihypertensive medication	na	> 140/90 or antihypertensive medication	> 130/80
Primary outcome, parent study	Macro‐ and microvascular complications	24‐hour creatinine clearance	Nephropathy	eGFR	Death, CVD events	Macro‐ and microvascular complications	GFR	Microalbuminuria	BP control	Macrovascular diabetic complications
Type of intervention:
More BP control	ACEi or β blocker	ACEi or CCA	Intensive intervention	Patient participation in education and care	Stepped antihypertensive medication	ACEi or  diuretic	ACEi or CCB	ACEi, ndCCB, or combination	Nurse management	"Intensive intervention"
Less BP control	No ACEi or β blocker	Placebo	Conventional treatment	Standard care	Routine care	Placebo	CCB or placebo	Placebo	Usual care	Conventional intervention
Blood pressure target:
More BP control	< 150/85 mmHg	DBP < 75 mmHg	< 140/85 (< 130/80c)	< 130/85 mmHg	≤ 120/80 mmHg	na	< 120/80 mmHg	< 120/80 mmHg	≤ 140/80 mmHg	≤ 120/75 mmHg
Less BP control	< 180/105 mmHg	DBP 80 to 89 mmHg	< 160/95 (< 135/85c)	na	≤ 135/85 mmHg	na	< 120/80 mmHg	< 120/80 mmHg	≤ 140/80 mmHg	≤ 130/80 mmHg
Other randomized intervention(s)	Intense glucose control vs standard	None	None	None	Intense glucose and cholesterol control vs standard	Intense glucose control vs standard	None	ndCCB vs placebo	None	None
Method of DR diagnosis	Photos graded centrally.	Photos graded centrally.d	Photos graded centrally.e	Fundus exams	Photos graded centrally.e	Photos graded centrally.f	Fundus exams + photos	Fundus exams + photos	Diagnosis in electronic chart	Fundus exams + records

^aDate of earliest publication.
^bAs defined by investigators.
^cFrom 2000.
^dWisconsin Fundus Photograph Reading Center.
^eBaseline photos taken up to 3 months before/after randomization.
^fAdRem Sub‐study Coordination Centre, Utrecht, the Netherlands.
 

ACEi, angiotensin converting enzyme inhibitor
BP, blood pressure (systolic/diastolic) or other
CCA, calcium channel antagonist
CCB, calcium channel blocker
CVD, cardiovascular disease
DBP, diastolic blood pressure, mmHg
DR, diabetic retinopathy
eGFR, estimated glomerular filtration rate
GFR, glomerular filtration rate
na, information not found in study publications
ndCCBs, non‐dihydropyridine calcium channel blockers
SBP, systolic blood pressure, mmHg