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. 2023 Mar 28;6:58. doi: 10.1038/s42004-023-00852-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a DNP-enhanced quantitative ¹³C-CPMAS spectra of CNF-prodrug-pH3/6 (in red) and CNF-prodrug-pH6 (in black), both acquired with the MultiCP pulse sequence⁷⁹. The two spectra were scaled to match the cellulose signals. b DNP-enhanced ¹⁵N-CPMAS spectra of CNF-prodrug-pH3/6 (in red) and CNF-prodrug-pH6 (in black). The ¹³C CPMAS spectrum (without DNP) of the Boc-protected cipro (crystalline powder) is given as reference (in blue). Peak assignment based on comparison with the ¹⁵N spectrum of Boc-protected cipro and published data^80,81 is given in the figure. The ¹⁵N spectra were scaled such that the N1 peak ratio of the two CNF spectra reflects the difference by a factor of 2/3 in prodrug loading between the two samples, as determined in (a). The CNF-prodrug chemical structure is given at the top of the fig. with numbering of the nitrogen atoms.