Table 4.
Sensitivity analyses: mutually adjusted models with the three dietary patterns and overall mortality.
| HR (95% CI)a | ||||
|---|---|---|---|---|
| N (events) | N cases (events) | DRRD | ISD | ERDP |
| Multivariable modelb | 13,270 (2340) | 0.92 (0.87–0.96) | 1.06 (1.00–1.12) | 0.97 (0.92–1.03) |
| Time from diet measurement to diagnosis | ||||
| <5 years | 3842 (1086) | 0.92 (0.86–0.98) | 1.00 (0.92–1.1) | 0.96 (0.89–1.04) |
| 5 to <8 years | 2712 (528) | 0.92 (0.83–1.01) | 1.05 (0.92–1.2) | 0.96 (0.85–1.09) |
| 8 to <12 years | 3671 (489) | 0.92 (0.83–1.02) | 1.13 (0.99–1.28) | 1.00 (0.89–1.14) |
| 12 years or more | 3045 (237) | 0.85 (0.73–0.99) | 1.14 (0.94–1.38) | 1.06 (0.88–1.26) |
| Period of diagnosis (year) | ||||
| Before 2000 | 3491 (987) | 0.92 (0.85–0.99) | 1.02 (0.93–1.12) | 0.98 (0.90–1.07) |
| 2001–2003 | 3512 (680) | 0.90 (0.83–0.98) | 1.03 (0.93–1.15) | 0.89 (0.80–0.99) |
| 2004–2007 | 3470 (459) | 0.93 (0.84–1.04) | 1.07 (0.93–1.23) | 1.04 (0.91–1.18) |
| 2008 or later | 2797 (214) | 0.87 (0.75–1.02) | 1.18 (0.97–1.44) | 1.06 (0.88–1.29) |
| Excluding BC survivors | ||||
| With T2D or CVD | 10,697 (1758) | 0.90 (0.86–0.95) | 1.06 (0.99–1.14) | 1.02 (0.95–1.08) |
| With unknown stage of tumour | 5627 (1023) | 0.92 (0.86–0.99) | 1.10 (1.00–1.20) | 0.98 (0.90–1.06) |
| With unknown HER2 status | 4443 (639) | 0.89 (0.81–0.98) | 1.10 (0.98–1.23) | 1.00 (0.90–1.12) |
| Additional adjustmentsc | ||||
| By time from diet measurement to diagnosis (continuous) | 13,270 (2340) | 0.91 (0.87–0.96) | 1.05 (0.99–1.12) | 0.98 (0.92–1.03) |
| By period of diagnosis (categorical) | 13,270 (2340) | 0.92 (0.87–0.96) | 1.05 (0.99–1.12) | 0.98 (0.93–1.03) |
| By co-morbiditiesd | 13,270 (2340) | 0.91 (0.87–0.96) | 1.06 (1.00–1.13) | 0.97 (0.92–1.02) |
aAll models are mutually adjusted with DRRD, ISD and ERDP by adding the residuals of the two remaining scores from the multiple regression models.
bModel from Table 2: stratified by country and menopausal status at diagnosis and adjusted for age at diagnosis, attained level of education, physical activity, body mass index, alcohol consumption reported at recruitment, smoking habit and intensity as cigarettes per day at recruitment, ever use of hormone for menopause at diagnosis, cancer stage at diagnosis, cancer grade, and tumour receptor status: ER, PR, HER2.
cNew variables added in the multivariable model.
dIncluding 2 co-morbidities: diabetes and a cardiovascular problem reported at recruitment.