Table 2.
Diagnostic accuracy of biomarkers for detecting endoscopically active disease [104]
| Parameter (95% CI) | CRP in IBD | SL in IBD | FC | |
|---|---|---|---|---|
| In IBD | In CD | |||
| Sensitivity | 0.49 (0.34–0.64) | 0.82 (0.73–0.88) | 0.88 (0.84–0.90) | 0.87 (0.82–0.91) |
| Specificity | 0.92 (0.72–0.98) | 0.79 (0.62–0.89) | 0.73 (0.66–0.79) | 0.67 (0.58–0.75) |
| Positive likelihood ratio | 6.3 (1.9–21.3) | 3.8 (2.0–7.5) | 3.2 (2.6–4.1) | 2.7 (2.1–3.4) |
| Negative likelihood ratio | 0.56 (0.44–0.71) | 0.23 (0.14–0.38) | 0.17 (0.14–0.21) | 0.19 (0.14–0.27) |
| AUC | 0.72 (0.68–0.76) | 0.87 (0.84–0.90) | 0.89 (0.86–0.91) | 0.85 (0.82–0.88) |
| Diagnostic odds ratio | 11 (3–38) | 16 (6–48) | 19 (13–27) | 14 (9–22) |
AUC area under the curve, CI confidence intervals, CRP C-reactive protein, FC fecal calprotectin, IBD inflammatory bowel disease, SL stool lactoferrin