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. Author manuscript; available in PMC: 2023 Mar 29.
Published in final edited form as: J Alzheimers Dis. 2023;92(2):395–409. doi: 10.3233/JAD-220599

Figure 1. Association of tissue-specific PRS with AD diagnosis (APOE included).

Figure 1.

The strength of association of each PRS (with the APOE locus included) with AD diagnosis (relative to cognitively unimpaired participants; MCI cases excluded) from the logistic regression models is shown (n = 1,115). The horizontal lines indicate thresholds for significance, with the black line indicating the nominal threshold of P = 0.05 and the red line indicating the Bonferroni-corrected threshold of P = 0.0036. All PRS scores were statistically significantly associated with AD diagnosis, with the liver PRS being the most strongly associated score.