Table 1.

Definitions of NIDA PhAB domains and major HiTOP dimensions.

	NIDA PhAB Domains
Metacognition	Cognitive awareness of one’s own thoughts (i.e., thinking about thinking).
Executive Function †	Higher order thought processes, including working memory, flexible thinking, and inhibitory control.
Interoception	Awareness and processing of internal bodily states/sensations.
Reward †	The incentive salience/motivational drive associated with a given substance.
Negative Emotionality †	The tendency to negatively perceive/experience events and circumstances and exhibit a negative emotional response (e.g., anger, hostility, sadness, anxiety).
Sleep	Sleep habits/patterns and quality of sleep experienced.
	Major HiTOP Dimensions
Internalizing	Experience of negative emotionality.
Somatoform	Experience of physical bodily symptoms in the presence of psychological distress.
Thought Disorder	Unconventional and creative thinking, as well as perceptions and cognitions that are loosely tethered to reality.
Detachment	Reduced volition, sociability, and affective expression.
Disinhibited Externalizing	Acting on impulse, without consideration for potential consequences.
Antagonistic Externalizing	Navigating interpersonal situations using antipathy and conflict, and to hurt other people intentionally, with little regard for their rights and feelings.

Note.

^†= also included in the Addictions Neuroclinical Assessment.