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. 2023 Mar 28;13:5072. doi: 10.1038/s41598-023-31781-8

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Photomicrograph of haematoxylin and eosin-stained sections from hippocampus of obese male rat (a–c) and obese female rats (d–f) treated with 15 mg of zinc showing partial improvement, where; (a) preservation of small pyramidal neurons with many apoptotic cells (↑); (b) marked apoptosis of large pyramidal neurons (↑) with few normal cells (right pointing triangle) and (c) decreased population of granular cells (|) with marked disorganization and vacuolation (V). Molecular layer (ML) mostly shows marked enlargement of neurons (↕) and many glial cells (wavy arrow); (d) preservation of small pyramidal cells (right pointing triangle) with many apoptotic cells (↑); (e) marked apoptosis of some large pyramidal cells (↑) and (f) decreased population of granular cells (|) with marked disorganization with less vacuolation (V). Molecular layer (ML) mostly shows marked enlargement of many neurons (↕) and many glial cells (wavy arrow) (H & E, ×400).