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Proposed mechanism of β2AR signaling mediated re-engineering of CD40-CD40L signaling in DCs. An increase in intracellular pIkBα (pIkBα) level with αCD40 treatment is reversed by β2AR signaling, thereby resulting in an altered cytokine production and immuno-retardation of anti-tumor response. Adapted from “NF-KB Signaling Pathway”, by BioRender.com (2022). Retrieved from https://app.biorender.com/biorender-templates.
