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. 2023 Mar 15;15:1132808. doi: 10.3389/fnagi.2023.1132808

Figure 2.

Figure 2

Serum NFL levels in different ALS motor phenotypes. (A) sNFL levels in all individual motor phenotypes of ALS. (B) sNFL levels in the three grouped ALS motor phenotypes according to UMN or LMN impairment. (C) ROC curve for the discrimination between PLS and UMNp ALS. In (A,B) wide horizontal bars represent median values, narrower horizontal bars represent first and third quartiles. AUC, area under the curve; CI, confidence interval; LMN, lower motor neuron; NFL, neurofilament light chain; PLS, primary lateral sclerosis; PMA, progressive muscular atrophy; ROC, receiver operating characteristic; sNFL, serum neurofilament light chain; UMN, upper motor neuron; UMNp, upper-motor-neuron-predominant ALS.