Table 3.
B-cell phenotype in immune responders (IR) and discordant immune responders (DIR).
| T0 | T1 | T2 | ||||||
|---|---|---|---|---|---|---|---|---|
| IR (n= 9) | DIR (n= 22) | IR (n= 22) | DIR (n= 24) | IR (n= 18) | DIR (n= 23) | p (IR) | p (DIR) | |
| % B cells | 11.5 (8.6-17.8) | 14.1 (9.6-19.6) | 8.4 (4.9-14.0) | 11.6 (8.0-15.0) | 10.5 (6.4-15.5) | 11.0 (7.1-14.1) | 0.011 | <0.001 |
| % Naïve B cells | 26.0 (21.5-41.4) | 32.3 (22.8-37.8) | 37.7 (26.2-42.3) | 44.3 (27.1-51.7) | 38.1 (27.1-41.5) | 42.8 (34.6-52.1) | 0.009 | <0.001 |
| % Memory B cells | 18.3 (14.2-28.4) | 14.7 (6.8-23.5) | 20.0 (11.1-37.2) | 15.6 (6.1-27.2) | 18.8 (11.2-27.4) | 15.2 (7.4-17.3) | 0.513 | 0.073 |
| % ASC B cells | 0.2 (0.1-0.9) | 0.3 (0.1-0.3) | 0.2 (0.1-0.8) | 0.3 (0.2-0.5) | 0.1 (0.1-0.2) | 0.3 (0.1-0.5) | 0.368 | 0.580 |
| % SARS-CoV-2-specific memory B cells | — | — | 0.3 (0.2-0.3) | 0.3 (0.2-0.7) | 0.4 (0.3-0.6) | 0.5 (0.4-1.1) | <0.001 | 0.144 |
| % SARS-CoV-2-specific memory B cells IgM+ | — | — | 42.2 (24.2-50.0) | 29.3 (12.2-48.5) | 18.4 (9.0-38.6) | 17.1 (7.1-27.6) | 0.007 | 0.019 |
| % SARS-CoV-2-specific memory B cells IgM− | — | — | 56.2 (50.0-75.8) | 61.4 (25.7-80.0) | 81.6 (61.4-91.0) | 83.3 (69.0-92.9) | 0.005 | 0.003 |
ASC, antibody-secreting cells.