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. 2023 Mar 15;14:1130308. doi: 10.3389/fimmu.2023.1130308

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Copyright © 2023 Zhuang, Cao, Liu, Wang, Lin, Duan, Lee, Chiu, Yeung and Yao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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HLA-G study based on JEG-3 trophoblast organoids and the CRISPR/Cas9 approach. (A) Schematic illustration of the formation of the trophoblast organoid and differentiation model. Red, orange, green, blue, and purple represent TB-ORG formation, ST differentiation, EVT differentiation, HLA-G knockout, and exogenous HLA-G treatment, respectively. (B) Genomic sequence for the HLA-G knockout targeted region. The PAM sequences are indicated in red. The small guide RNA sequences are underlined in green.