Table 1.

Comparison between two-dimensional JEG-3 and JEG-3-ORGs.

		2D JEG-3	JEG-3-ORGs
Difference	Culture medium	10% FBS+DMEM/F12	Turco’s medium (5), B. Dietrich’s medium (6)
	Morphology	Monolayered epithelial cell, EVT-like phenotype (19)	Multilayered epithelial spheroids, Stem cell-like phenotype (6)
	Functional research	Invasion (16, 17), NK cytotoxicity (42), Angiopoiesis	Trophoblast differentiation, Interaction with endometrium
Same		Choriocarcinoma-derived, expressed HLA-G, drug screening