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. 2023 Mar 15;14:1130308. doi: 10.3389/fimmu.2023.1130308
HLA-G Human leucocyte antigen G
EVT extravillous trophoblasts
WT wild type
KO knockout
TB-ORGs trophoblast organoid
CTBs cytotrophoblasts
STB syncytiotrophoblast
MHC major histocompatibility complex
sg-RNAs small guide RNAs
DEGs differentially expressed genes;
TPM transcripts per million
GO Gene Ontology
KEGG Kyoto Encyclopedia of Genes and Genomes
TE trophectoderm
TSC trophoblast stem-cell
TESC trophectoderm stem cell
CCTs cell column trophoblasts
Wnt Wingless-Type
TGF-beta transforming growth factor beta
MAPK Mitogen-Activated Protein Kinase;
PI3K-Akt Phosphatidylinositol-3-kinase protein kinase B;
GATA3 GATA Binding Protein 3
TFAP2A Transcription Factor AP-2 Alpha
TFAP2C Transcription Factor AP-2 Gamma;
CDX2 Caudal Type Homeobox 2
TP63 Tumor Protein P63;
EGFR Epidermal Growth Factor Receptor
POU5F1 (OCT4) POU Class 5 Homeobox 1
KRT7 Keratin 7
ELF5 E74 like ETS transcription factor 5
HAND1 Heart and neural crest derivatives expressed 1
ID1 inhibitor of DNA binding 1
MMP Matrix Metallopeptidase
TIMP Tissue Inhibitor Of Metalloproteinase;
ITGA Integrin Subunit Alpha
ERBB Erb-B2 Receptor Tyrosine Kinase
DAO diamine oxidase
PAPPA2 Pappalysin 2
IGF insulin-like growth factor
GDF Growth Differentiation Factor;
PSG pregnancy specific glycoprotein family
HIST histone
SAMD4 SMAD Family Member 4
CTNNBIP1 Catenin Beta Interacting Protein 1
MCAM Melanoma Cell Adhesion Molecule
TCF4 Transcription Factor 4
SOX2 SRY-Box Transcription Factor 2.