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Structure of DDR1 and DDR2. There are five isoforms of DDR1. Among them, the kinase activity is present in the DDR1a, DDR1b and DDR1c coding sequences, but not in the DDR1d or DDR1e. However, only one single isoform of DDR2 exists. DDR, discoidin domain receptor; DS, discoidin domain; EJM, extracellular juxta-membrane; IJM, intracellular juxta-membrane; KD, kinase domain; TM, transmembrane domain. (The figure is drawn by Figdraw).
