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. 2023 Mar 15;13:1140277. doi: 10.3389/fonc.2023.1140277

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Copyright © 2023 Huang, Gao, Li, Yang, Jiang, Liao, Luo and Lu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Contrast-enhanced US images from a 68-year-old man with chronic hepatitis B. A hypoechoic mass measuring 5 cm was detected in segment V of the liver. On SonoVue enhanced-US, the mass showed nonrim arterial phase hyperenhancement (APHE) (A, white arrow) followed by early washout in thirty-six seconds (B, white arrow) and hypoenhancement in the late phase (C, white arrow). On Sonazoid-enhanced US, the mass manifested nonrim APHE (D), white arrow) and early washout (E, white arrow) followed by an enhancement defect in the Kupffer phase (F, white arrow). The mass confirmed intrahepatic cholangiocarcinoma by histopathology.