Table 4.
Comparison of CEUS features of HCC with different pathological differentiation and tumor size according to contrast agent used.
| Variable | Non-rim APHE | Rim APHE | Late (≥60 s) and Mild Washout | Early Washout (< 60 s) |
No Washout | Kuppfer Phase Filling Defect | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Sonovue | Sonazoid | Sonovue | Sonazoid | Sonovue | Sonazoid | Sonovue | Sonazoid | Sonovue | Sonazoid | ||
| Differentiation degree (n=52) | |||||||||||
| Well-differentiated (n=2) | 2 (100) | 2 (100) | 0 (0) | 0 (0) | 2 (100) | 1 (50) | 0 (0) | 0 (0) | 0 (0) | 1 (50) | 1 (50) |
| Moderately-differentiated (n=34) | 32 (94.1) | 32 (94.1) | 2 (5.9) | 2 (5.9) | 25 (73.5) | 23 (67.6) | 9 (26.5) | 10 (29.4) | 0 (0) | 1 (2.9) | 34 (100) |
| Poorly- differentiated (n=16) | 16 (100) | 16 (100) | 0 (0) | 0 (0) | 14 (87.5) | 14 (87.5) | 2 (12.5) | 2 (12.5) | 0 (0) | 0 (0) | 16 (100) |
| Tumor size (n=55) | |||||||||||
| ≤2 cm (n=11) | 11 (100) | 11 (100) | 0 (0) | 0 (0) | 10 (90.9) | 9 (81.8) | 1 (9.1) | 1 (9.1) | 0 (0) | 1 (9.1) | 10 (90.9) |
| >2 cm (n=44) | 42 (95.5) | 42 (95.5) | 2 (4.5) | 2 (4.5) | 34 (77.3) | 32 (72.7) | 10 (22.7) | 11 (26.2) | 0 (0) | 1 (2.3) | 44 (100) |
Data are numbers of nodules with percentage in parentheses. CEUS, contrast enhanced ultrasound; HCC, hepatocellular carcinoma; APHE, arterial phase hyperenhancement.