Table 5.
Diagnostic performances for hepatocellular carcinoma according to contrast agent used.
| Variable | CEUS LR-5 | p Value* | Modified LR-5 | p Value† | |
|---|---|---|---|---|---|
| Sonovue | Sonazoid | Sonazoid | |||
| Sensitivity | 80 (44/55) [67, 89.6] | 74.6 (41/55) [61, 85.3] | 0.25 | 76.4 (42/55) [63, 86.8] | 0.99 |
| Specificity | 100 (7/7) [59, 100] | 100 (7/7) [59,100] | 1 | 100 (7/7) [59, 100] | 1 |
| Accuracy | 82.3 (51/62) [70.5, 90.8] | 77.4 (48/62) [65, 87.1] | 0.25 | 79 (49/62) [66.8, 88.3] | 0.99 |
Data are numbers of nodules; data in parentheses are percentages. CEUS LI-RADS, contrast enhanced ultrasound Liver Imaging Reporting and Data System.
* The comparison between SonoVue-enhanced US and Sonazoid-enhanced US according to CEUS LI-RADS® 2017.
† The comparison between Sonazoid-enhanced US by using CEUS LI-RADS® 2017 and the modified criteria (using Kupffer-phase defects as an alternative to late and mild washout in CEUS LI-RADS).