Table 1.
Demographics of participantsa.
| eGFR < 60 (n = 112) | eGFR 60–90 (n = 418) | eGFR ≥ 90 (n = 115) | P | |
|---|---|---|---|---|
| Age | 77.95 (9.87) | 72.05(9.80) | 70.00 (6.85) | <0.001 |
| Sex:Female, No.(%) | 57 (50.9) | 194 (46.4) | 50 (43.5) | 0.526 |
| Education (years) | 16.50 (5.00) | 16.00 (4.00) | 16.00 (4.00) | 0.37 |
| ≥1 APOE ε4, No.(%) | 44 (39.3) | 195 (46.6) | 60 (52.2) | 0.147 |
| Diagnose, No.(%) CN | 38 (33.9) | 89 (21.3) | 25 (21.7) | 0.12 |
| SMC | 1 (0.9) | 13 (3.1) | 2 (1.7) | |
| EMCI | 32 (28.6) | 160 (38.3) | 50 (43.5) | |
| LMCI | 24 (21.4) | 85 (20.3) | 23 (20.0) | |
| AD | 17 (15.2) | 71 (17.0) | 15 (13.0) | |
| Creatinine (mg/dL) | 1.30 (0.30) | 1.00 (0.20) | 0.80 (0.20) | <0.001 |
| eGFR | 53.38 (9.61) | 72.59 (12.20) | 93.80 (4.48) | <0.001 |
| Aβ-PET positive, No.(%) | 61 (54.5) | 228 (54.5) | 58 (50.4) | 0.727 |
| Plasma Aβ42/40 | 0.12 (0.02) | 0.12 (0.02) | 0.12 (0.01) | 0.461 |
| p-tau181 (pg/mL) | 19.25 (14.00) | 15.60 (12.64) | 15.45 (11.64) | 0.012 |
| NfL (pg/mL) | 44.45 (30.45) | 33.60 (19.14) | 27.15 (15.48) | <0.001 |
aData are presented as the mean ± standard deviation for normally distributed variables, median and interquartile range (IQR) for skewed distributed variables, and number (%) for categorical variables.