Table 3.
Diagnostic performance of plasma biomarkers in participants with different renal function.
| Na (N+, N−) | AUC (95% CI) | p value (compared with eGFR <60) | Cutoffb | Sensitivity | Specificity | PPV | NPV | |
|---|---|---|---|---|---|---|---|---|
| Aβ42/40 | ||||||||
| eGFR <60 | 54 (28,26) | 0.80 (0.68–0.93) | – | 0.12 | 0.93 | 0.65 | 0.74 | 0.89 |
| eGFR 60–90 | 217 (100,117) | 0.85 (0.79–0.90) | 0.51 | 0.12 | 0.77 | 0.86 | 0.83 | 0.81 |
| eGFR ≥90 | 62 (22,40) | 0.78 (0.66–0.90) | 0.782 | 0.12 | 0.91 | 0.63 | 0.57 | 0.93 |
| p-tau181 | ||||||||
| eGFR <60 | 111 (60,51) | 0.80 (0.71–0.89) | – | 14.49 | 0.88 | 0.63 | 0.74 | 0.82 |
| eGFR 60–90 | 414 (226,188) | 0.74 (0.69–0.79) | 0.252 | 15.15 | 0.71 | 0.72 | 0.75 | 0.67 |
| eGFR ≥90 | 114 (58,56) | 0.82 (0.74–0.89) | 0.778 | 18.74 | 0.62 | 0.89 | 0.86 | 0.69 |
| NfL | ||||||||
| eGFR <60 | 110 (60,50) | 0.69 (0.59–0.79) | – | 34.9 | 0.87 | 0.48 | 0.67 | 0.75 |
| eGFR 60–90 | 414 (226,188) | 0.67 (0.61–0.72) | 0.686 | 29.35 | 0.77 | 0.48 | 0.64 | 0.64 |
| eGFR ≥90 | 114 (58,56) | 0.72 (0.62–0.81) | 0.691 | 33.7 | 0.48 | 0.89 | 0.82 | 0.63 |
aN represents whole sample, N+ represents Aβ-PET positive sample, N− represents Aβ-PET negative sample. bCutoff values were calculated by Youden-Index.