Fig. 11.

Imidazole-poly (organophosphazenes) (I-5) injectable hydrogel for SCI repair in a rat with spinal contusion injury. a) A viscometer's measurement of temperature-dependent sol-gel transition and viscosity changes. b) Demonstration of the rapid gelation of an I-5 polymer solution at 4 ​°C and 37 ​°C. c, d) After four weeks of I-5 injection, there are no cystic cavity areas; (sections of spinal cord stained with (c) eriochrome cyanine and eosin a (d) GFAP antibodies). e) Three-dimensional regeneration of animal spinal cord tissues. f) Quantification diagrams that display the cavity volumes, pathological tissue, and myelinated white matter. g) Four weeks after injury, animals that had received an I-5 injection displayed improved BBB locomotor scores. h) Catwalk software analysis of representative footprints. i) After seven weeks of injury parameters such as stride length, the base of support, rotation angle, relative position, and regularity index were used to measure the quality of locomotion. j, k) The prevention of motor neurons and myelinated white matter after I-5 injection; (The samples were stained with (j) eriochrome cyanine and cresyl violet and (k) myelin basic protein immunostaining) [223]. Copyright 2017 Nature.