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Binding mode analysis of wogonin and Mpro. Two perpendicular views are shown. Mpro is indicated as ribbon (yellow) and cylinder (denotes residues, green). Wogonin is shown in ball-and-stick models (purple). Protomer A (catalytically competent enzyme) is presented on the left and protomer B (inactive enzyme) is shown on the right. Domain I (residues 8−101), domain II (residues 102−184), and domain III (residues 201−306) can be seen.
