Skip to main content
Annals of the Rheumatic Diseases logoLink to Annals of the Rheumatic Diseases
. 1993 Jul;52(7):548–550. doi: 10.1136/ard.52.7.548

Long term follow up of radiosynovectomy with yttrium-90 silicate in haemophilic haemarthrosis.

M E van Kasteren 1, I R Nováková 1, A M Boerbooms 1, J A Lemmens 1
PMCID: PMC1005098  PMID: 8346985

Abstract

OBJECTIVES--The aim of this study was to evaluate the long term effect of radiation synovectomy with yttrium-90 silicate in haemophiliac patients with recurrent haemarthrosis. METHODS--The bleeding frequency and the mobility of the joint were recorded in 16 joints of 14 patients 1 year before radiosynovectomy and during follow up, which ranged from 3 to 6 years. Patients evaluated the effect of their own treatment by completing a questionnaire. Radiographs of the joints were scored by an independent radiologist before treatment. RESULTS--A satisfactory reduction of the frequency of haemorrhage was achieved in 94% of joints during the first year after treatment and was maintained in 63% until the end of the follow up period. In general there was no decrease in mobility attributable to radiosynovectomy, and the patients' own evaluations agreed with the evaluations based on the frequencies of haemarthrosis in 75%. Patients who had only minor, or no, radiological abnormalities of the joints before treatment showed the best results. One patient developed synovitis as a complication of the radiosynovectomy. CONCLUSION--Radiosynovectomy is an effective and safe treatment for recurrent haemarthrosis in haemophiliac patients, especially in those who have joints with no or minor radiological damage.

Full text

PDF
548

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ahlberg A., Pettersson H. Synoviorthesis with radioactive gold in hemophiliacs. Clinical and radiological follow-up. Acta Orthop Scand. 1979 Oct;50(5):513–517. doi: 10.3109/17453677908989797. [DOI] [PubMed] [Google Scholar]
  2. Boerbooms A. M., Buijs W. C., Danen M., van de Putte L. B., Vandenbroucke J. P. Radio-synovectomy in chronic synovitis of the knee joint in patients with rheumatoid arthritis. Eur J Nucl Med. 1985;10(9-10):446–449. doi: 10.1007/BF00256588. [DOI] [PubMed] [Google Scholar]
  3. Fernandez-Palazzi F., de Bosch N. B., de Vargas A. F. Radioactive synovectomy in haemophilic haemarthrosis. Follow-up of fifty cases. Scand J Haematol Suppl. 1984;40:291–300. doi: 10.1111/j.1600-0609.1984.tb02575.x. [DOI] [PubMed] [Google Scholar]
  4. Franssen M. J., Boerbooms A. M., Karthaus R. P., Buijs W. C., van de Putte L. B. Treatment of pigmented villonodular synovitis of the knee with yttrium-90 silicate: prospective evaluations by arthroscopy, histology, and 99mTc pertechnetate uptake measurements. Ann Rheum Dis. 1989 Dec;48(12):1007–1013. doi: 10.1136/ard.48.12.1007. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Gumpel J. M. The role of radiocolloids in the treatment of arthritis. Rheumatol Rehabil. 1974 Feb;13(1):1–9. doi: 10.1093/rheumatology/13.1.1. [DOI] [PubMed] [Google Scholar]
  6. Jankowski J. Organ doses in diagnostic X-ray procedures. Health Phys. 1984 Jan;46(1):228–234. [PubMed] [Google Scholar]
  7. Madhok R., York J., Sturrock R. D. Haemophilic arthritis. Ann Rheum Dis. 1991 Aug;50(8):588–591. doi: 10.1136/ard.50.8.588. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Pettersson H., Ahlberg A., Nilsson I. M. A radiologic classification of hemophilic arthropathy. Clin Orthop Relat Res. 1980 Jun;(149):153–159. [PubMed] [Google Scholar]
  9. Roberts S. D., Gillespie P. J. Effect of immobilization on retention of 90Y. Ann Rheum Dis. 1973 Dec;32 (Suppl 6)(Suppl 6 Suppl):46–47. doi: 10.1136/ard.32.suppl.46. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Sokoloff L. Biochemical and physiological aspects of degenerative joint diseases with special reference to hemophilic arthropathy. Ann N Y Acad Sci. 1975 Jan 20;240:285–290. doi: 10.1111/j.1749-6632.1975.tb53362.x. [DOI] [PubMed] [Google Scholar]
  11. de la Chapelle A., Rekonen A., Oka M., Ruotsi A. Chromosome damage after intra-articular injections of radioactive yttrium. Effect of immobilization on the biological dose. Ann Rheum Dis. 1972 Nov;31(6):508–512. doi: 10.1136/ard.31.6.508. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. van Creveld S., Hoedemaeker P. J., Kingma M. J., Wagenvoort C. A. Degeneration of joints in haemophiliacs under treatment by modern methods. J Bone Joint Surg Br. 1971 May;53(2):296–302. [PubMed] [Google Scholar]
  13. van't Pad Bosch P. J., van de Putte L. B., Boerbooms A. M., Geerdink P. J. Radiosynoviorthesis in haemophilic joint disease. Z Rheumatol. 1981 Nov-Dec;40(6):237–239. [PubMed] [Google Scholar]

Articles from Annals of the Rheumatic Diseases are provided here courtesy of BMJ Publishing Group

RESOURCES