Table 1. Baseline Characteristics of Patients With Small NF-PanNETs With or Without Surgical Resection by Tumor Size.
| Characteristic | Patients, No. (%) | P value | |
|---|---|---|---|
| With surgical resection (n = 3974) | Without surgical resection (n = 667) | ||
| Group 1a: tumor size ≤1.0 cm (n = 1278) | |||
| No. of patients | 1048 | 230 | |
| Age, median (IQR), y | 61 (52-69) | 65 (57-73) | <.001 |
| Sex | |||
| Male | 464 (44.3) | 113 (49.1) | .19 |
| Female | 584 (55.7) | 117 (50.9) | |
| Facility type | |||
| Nonacademic | 224 (21.4) | 53 (23.0) | .48 |
| Academic | 757 (72.2) | 167 (72.6) | |
| Missing data | 67 (6.4) | 10 (4.4) | |
| Charlson-Deyo comorbidity index | |||
| 0 | 700 (66.8) | 177 (77.0) | <.001 |
| 1 | 263 (25.1) | 28 (12.2) | |
| 2-3 | 85 (8.1) | 25 (10.8) | |
| Primary site | |||
| Head | 255 (24.3) | 66 (28.7) | <.001 |
| Body | 205 (27.2) | 94 (40.9) | |
| Tail | 508 (48.5) | 70 (30.4) | |
| Clinical lymph node metastasis | |||
| Negative | 835 (79.7) | 216 (93.9) | <.001 |
| Positive | 25 (2.4) | 2 (0.9) | |
| Missing data | 188 (17.9) | 12 (5.2) | |
| Chemotherapy | |||
| No | 1029 (98.2) | 224 (97.4) | .23 |
| Single agent | 8 (0.8) | 2 (0.9) | |
| Multiple agents | 4 (0.3) | 2 (0.9) | |
| Yes (unknown agent) | 0 | 1 (0.4) | |
| Missing data | 7 (0.7) | 1 (0.4) | |
| Histologic distribution | |||
| Islet cell (NOS) | 57 (5.4) | 5 (2.2) | <.001 |
| Well-differentiated NET | 601 (57.3) | 175 (76.1) | |
| Moderately differentiated NET | 12 (1.1) | 5 (2.2) | |
| NEN (NOS) | 378 (36.0) | 45 (19.5) | |
| Tumor differentiation | |||
| Well | 970 (92.6) | 211 (91.7) | .68 |
| Moderate | 78 (7.4) | 19 (8.3) | |
| Group 1b: tumor size 1.1-2.0 cm (n = 3363) | |||
| No. of patients | 2926 | 437 | |
| Age, median (IQR), y | 61 (52-69) | 69 (60-76) | <.001 |
| Sex | |||
| Male | 1520 (51.9) | 241 (55.1) | .22 |
| Female | 1406 (48.1) | 196 (44.9) | |
| Facility type | |||
| Nonacademic | 554 (19.0) | 119 (27.2) | <.001 |
| Academic | 2157 (73.7) | 304 (69.6) | |
| Missing data | 215 (7.3) | 14 (3.2) | |
| Charlson-Deyo comorbidity index | |||
| 0 | 2073 (70.9) | 310 (70.9) | .11 |
| 1 | 627 (21.4) | 82 (18.8) | |
| 2-3 | 226 (7.7) | 45 (10.3) | |
| Primary site | |||
| Head | 790 (27.0) | 175 (40.0) | <.001 |
| Body | 634 (21.7) | 121 (27.7) | |
| Tail | 1502 (51.3) | 141 (32.3) | |
| Clinical lymph node metastasis | |||
| Negative | 2341 (80.0) | 404 (92.4) | <.001 |
| Positive | 65 (2.2) | 9 (2.1) | |
| Missing data | 520 (17.8) | 24 (5.5) | |
| Chemotherapy | |||
| No | 2867 (98.0) | 411 (94.1) | <.001 |
| Single agent | 13 (0.4) | 8 (1.8) | |
| Multiple agents | 7 (0.2) | 5 (1.1) | |
| Yes (unknown agent) | 1 (0.1) | 2 (0.5) | |
| Missing data | 38 (1.3) | 11 (2.5) | |
| Histologic distribution | |||
| Islet cell (NOS) | 192 (6.6) | 17 (3.9) | <.001 |
| Well-differentiated NET | 1628 (55.6) | 318 (72.8) | |
| Moderately differentiated NET | 144 (4.9) | 11 (2.5) | |
| NEN (NOS) | 962 (32.9) | 91 (20.8) | |
| Tumor differentiation | |||
| Well | 2520 (86.1) | 385 (88.1) | .30 |
| Moderate | 406 (13.9) | 52 (11.9) | |
Abbreviations: NEN, neuroendocrine neoplasm; NET, neuroendocrine tumor; NF-PanNETs, nonfunctional pancreatic neuroendocrine tumors; NOS, not otherwise specified.