Table 1.
Epidemiological studies assessing the association between dried fruit intake and cancer risk published since 2019.
| Study Type | Participants | Cancer Type | Outcome (95% CI) | Reference |
|---|---|---|---|---|
| Systematic review | n = 437,298 from 16 studies | Pancreatic, prostate, colorectal polyps | Dose-response trend from prospective studies | Mossine et al., 2020 [51] |
| Stomach, pancreatic, colorectal, nasopharyngeal, bladder | Total dried fruit, raisins, or dates reduced incidence from case–control studies | |||
| Cohort | UK Women’s Cohort Study (n = 35,372 women aged 35–69 in England, Wales, and Scotland) | Breast | HR 1.04 (0.98,1.13) | Dunneram et al., 2019 [60] |
| Endometrial | HR 0.60 (0.37, 0.97) | |||
| Ovarian | HR 1.06 (0.89, 1.26) | |||
| Prospective cohort | National Institutes of Health-American Association of Retired Persons Diet and Health Study (n = 485,403 men and women aged 50–71 at baseline in the United States) | Liver | HR (Q5 vs. Q1) 0.73 (0.60, 0.89) | Zhao et al., 2022 [61] |
| Mendelian randomization | UK Biobank (n ~500,000 men and women aged 49–69 in the United Kingdom) | Oral cavity/pharyngeal | IVW OR 0.17 (0.04, 0.69) | Jin et al., 2022 [62] |
| Lung | IVW OR 0.33 (0.17, 0.64) | |||
| Squamous cell lung | IVW OR 0.23 (0.09, 0.60) | |||
| Breast | IVW OR 0.47 (0.32, 0.68) | |||
| Pancreatic | IVW OR 0.03 (0.001, 0.68) | |||
| Cervical | IVW OR 0.99 (0.9897, 0.9998) | |||
| Lung adenocarcinoma, endometrial, thyroid, prostate, bladder, brain | IVW OR not significant |
Abbreviations: HR, Hazard ratio; IVW, Inverse variance weighted; OR, Odds ratio.