Table 1. . GAC, KGA, and GAC show distinct enzymatic activity profiles in the presence of phosphate.
Isoform | Ka for Pi (mM) | kcat (s-1) | KM for glutamine (mM) | Cooperativity |
---|---|---|---|---|
GAC | 80 ± 8 | 22 ± 2 | 1.4 ± 0.4 | Michaelis-Menten kinetics |
KGA | 76 ± 7 | 10 ± 1 | 1.9 ± 0.4 | Michaelis-Menten kinetics |
LGA | 8 ± 1 | 2.5 ± 0.3 | 4.0 ± 0.2 | Positive cooperativity |
Table adapted from DeLaBarre et al. [39].