Figure 1.

Neutrophils have a significant impact on early event of acute lung inflammation. The formation of granulation tissue, which is made up of cellular matrix, fibroblasts, endothelial cells, and leukocytes, is orchestrated by neutrophil migration and chemokine production during acute inflammation. Inflammation becomes chronic when acute inflammation is not treated. Other inflammatory immune cells, such as macrophages and lymphocytes, intensify lung inflammation during chronic inflammation, increasing the risk of cancer by fostering tumorigenesis at all stages, including initiation, invasion, and metastasis. Lung cancer progression is also aided by inflammation because it supplies the tumor microenvironment with vital molecules by the help of extracellular vesicles.