Figure 4. Multivariable-Adjusted Hazard Ratios and 95% CIs for Cardiovascular Disease (CVD) Across Strata of Genetic CVD, Ischemic Stroke, or Coronary Artery Disease Risk, With Healthful Plant-based Diet Index (hPDI) Score Modeled as a Continuous Trend (10-Point Increments).

Analyses used age as the underlying time variable and were adjusted for sex, body mass index, race and ethnicity, physical activity level, smoking status, alcohol intake, education level, energy intake, polypharmacy index, multimorbidity index, and aspirin use, stratified by region. Heterogeneity was tested by comparing 2 models: one model without an interaction term between the subgroup of interest and hPDI compared with another model with an interaction term between the subgroup of interest and hPDI. The likelihood ratio test was used to produce P interaction values. HR indicates hazard ratio; PRS, polygenic risk score.