Table 3.
Factors (Independent Variables) | Levels |
---|---|
X1: PC amount (mg) | 50 100 |
X2: CH amount (mg) | 50 100 |
Responses (dependent variables) | Constraints |
Y1: EE (%) | Maximize |
Y2: PS (nm) | Maximize |
Y3: PDI | Minimize |
Y4: ZP (mV) | Maximize (absolute value) |
Y5: Q6h (%) | Minimize |
Abbreviations: EE%—entrapment efficiency percent, CH—cholesterol, PC—phospholipid, PS—particle size, PDI—polydispersity index, ZP—zeta potential, and Q6h—percent of drug released after 6 h.