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. 2023 Feb 24;21(3):149. doi: 10.3390/md21030149

Table 3.

A 22 full factorial design for the optimization of S. platensis loaded phytosomes.

Factors (Independent Variables) Levels
X1: PC amount (mg) 50       100
X2: CH amount (mg) 50       100
Responses (dependent variables) Constraints
Y1: EE (%) Maximize
Y2: PS (nm) Maximize
Y3: PDI Minimize
Y4: ZP (mV) Maximize (absolute value)
Y5: Q6h (%) Minimize

Abbreviations: EE%—entrapment efficiency percent, CH—cholesterol, PC—phospholipid, PS—particle size, PDI—polydispersity index, ZP—zeta potential, and Q6h—percent of drug released after 6 h.