Table 6.
Twenty-eight-day mortality and the need for mechanical ventilation in patients treated with remdesivir during periods of Delta and Omicron variant dominance analyzed in all patients, only those with oxygen saturation ≤95%, including administration of remdesivir within 5 days of symptom onset and those aged over 60 or 80 years.
| Patients Subpopulations | Mortality | Mechanical Ventilation | ||||
|---|---|---|---|---|---|---|
| Delta | Omicron | p | Delta | Omicron | p | |
| All patients, % (n/N) |
10.8 (53/490) |
11.4 (31/272) |
>0.05 | 7.8 (38/490) |
2.2 (6/272) |
0.002 |
| SpO2 ≤ 95%, % (n/N) |
11.8 (51/431) |
14.3 (28/196) |
>0.05 | 7.9 (34/431) |
3.1 (6/196) |
0.02 |
| SpO2 ≤ 95%, 0–5 days, % (n/N) | 13.3 (31/233) |
14.3 (23/161) |
>0.05 | 7.7 (18/233) |
2.5 (4/161) |
0.03 |
| SpO2 ≤ 95%, 0–5 days, >60 years, % (n/N) |
19.5 (30/154) |
15.4 (22/143) |
>0.05 | 9.1 (14/154) |
2.1 (3/143) |
0.01 |
| SpO2 ≤ 95%, 0–5 days, >80 years, % (n/N) |
35.3 (18/51) |
21.4 (12/56) |
>0.05 | 7.8 (4/51) |
1.8 (1/56) |
>0.05 |
Abbreviations: SpO2, saturation of peripheral oxygen.