Table 7.
Endpoints considering the time of RDV treatment initiation: within 5 days of symptom onset versus more than 5 days.
| Parameter | Delta | Omicron | ||||
|---|---|---|---|---|---|---|
| ≤5 | >5 | p | ≤5 | >5 | p | |
| All | ||||||
| n | 274 | 205 | 231 | 35 | ||
| Mortality, % (n) | 13.5 (37/274) |
7.8 (16/205) |
>0.05 | 10.8 (25/231) |
14.3 (5/35) |
>0.05 |
| Need for oxygen therapy, % (n) | 73 (200/274) |
83.9 (172/205) |
<0.001 | 56.7 (131/231) | 77.1 (27/35) |
0.0218 |
| Time of oxygen therapy, mean ± SD | 8.4 ± 9.4 | 10.1 ± 8.7 | >0.05 | 9.4 ± 7.0 | 11.2 ± 6.8 | >0.05 |
| Need for mechanical ventilation, % (n) | 8.8 (24/274) |
6.8 (14/205) |
>0.05 | 1.7 (4/231) |
5.7 (2/231) |
>0.05 |
| >60 years | ||||||
| n | 172 | 110 | 182 | 29 | ||
| Mortality, % (n) | 20.3 (35/172) |
10 (11/110) |
>0.05 | 12.6 (23/182) |
17.2 (5/29) |
>0.05 |
| Need for oxygen therapy, % (n) | 79.1 (136/172) |
27.3 (30/110) |
>0.05 | 63.7 (116/182) | 75.9 (22/29) |
>0.05 |
| Time of oxygen therapy, mean ± SD | 9.6 ± 9.9 | 10.7 ± 9.1 | >0.05 | 9.3 ± 7 | 10.3 ± 6.7 | >0.05 |
| Need for mechanical ventilation, % (n) | 9.9 (17/172) |
7.3 (8/110) |
>0.05 | 1.6 (3/182) |
0 (0/29) |
>0.05 |
| >80 years | ||||||
| n | 56 | 36 | 75 | 13 | ||
| Mortality, % (n) | 33.9 (19/56) |
16.7 (6/36) |
>0.05 | 16 (12/75) |
30.8 (4/13) |
>0.05 |
| Need for oxygen therapy, % (n) | 89.3 (50/56) |
83.3 (30/36) |
>0.05 | 62.7 (47/75) |
84.6 (11/13) |
>0.05 |
| Time of oxygen therapy, mean ± SD | 10.1 ± 8.9 | 10.9 ± 8.1 | >0.05 | 8.4 ± 5.6 | 11.7 ± 7.4 | >0.05 |
| Need for mechanical ventilation, % (n) | 8.9 (5/56) |
8.3 (3/36) |
>0.05 | 1.3 (1/75) |
0 (0/13) |
>0.05 |
Abbreviations: RDV, remdesivir; SD, standard deviation.