Table 2.
Opioids, laxatives, and antiemetic drugs used in this study.
| Opioids, Laxatives, and Antiemetics | % | |
|---|---|---|
| Daily opioid dose in oral morphine equivalents (mg) | ||
| Median (range) | 30 (7.5–600) | |
| <30 | 14 | 41.2 |
| 30–99 | 12 | 35.3 |
| ≥100 | 8 | 23.5 |
| Regular use of opioids (no. of patients) | ||
| Oxycodone | 20 | 58.8 |
| Fentanyl | 11 | 32.4 |
| Morphine | 2 | 5.9 |
| Hydromorphone | 1 | 2.9 |
| Days from the first opioid initiation to naldemedine treatment (days) | ||
| Median (range) | 5 (1–287) | |
| <4 | 9 | 26.5 |
| 4–7 | 3 | 8.8 |
| 8–14 | 3 | 8.8 |
| 15–28 | 7 | 20.6 |
| 29–99 | 9 | 26.5 |
| ≥100 | 3 | 8.8 |
| Concomitant laxatives * (no. of patients) | ||
| Magnesium oxide | 21 | 61.8 |
| Sennoside | 4 | 11.8 |
| Lubiprostone | 4 | 11.8 |
| Bisacodyl | 2 | 5.9 |
| Sodium picosulfate hydrate | 2 | 5.9 |
| Sodium bicarbonate, sodium dihydrogen phosphate anhydrous suppository | 1 | 2.9 |
| Others | 2 | 5.9 |
| Concomitant antiemetic drugs (regular and occasional use) * (no. of patients) | ||
| Prochlorperazine | 8 | 23.5 |
| Metoclopramide | 5 | 14.7 |
| Domperidone | 3 | 8.8 |
| Olanzapine | 2 | 5.9 |
| Others | 0 | 0 |
* Includes duplicate use.