Table 3.
Patient backgrounds based on response.
| Characteristic | Responder (n = 21) |
Non-Responder (n = 13) |
p-Value |
|---|---|---|---|
| Sex | |||
| Men/Women | 8/13 | 8/5 | 0.29 |
| Age | |||
| <75/≥75 | 13/8 | 8/5 | >0.99 |
| PS | |||
| 0–2/≥3 | 12/9 | 6/7 | 0.72 |
| Regular opioid dose (morphine equivalent; mg/day) | |||
| <30/≥30 | 7/14 | 7/6 | 0.29 |
| History of chemotherapy within 21 days prior to naldemedine initiation | |||
| Yes/no | 6/15 | 1/12 | 0.21 |
| History of abdominal surgery before naldemedine initiation | |||
| Yes/No | 9/12 | 1/12 | 0.05 |
| History of radiotherapy to the abdomen and pelvic region before naldemedine initiation | |||
| Yes/No | 2/19 | 0/13 | 0.51 |
| Presence of diabetes mellitus | |||
| Yes/No | 3/18 | 3/10 | 0.65 |
| Use of laxatives before the initiation of naldemedine | |||
| Yes/No | 16/5 | 11/2 | 0.68 |
| Concomitant use of laxatives during naldemedine treatment | |||
| Yes/No | 17/4 | 7/6 | 0.12 |
PS, performance status.