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. 2023 Mar 9;13(3):404. doi: 10.3390/metabo13030404

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Role of apigenin and isovitexin in cancer management through the modulation of different signaling pathways. The complex cell nature of the tumor is characterized by a number of molecular interactions and mechanisms. Abbreviations: Bax, BCL2-associated x protein; Bcl-2, B-cell lymphoma 2; Cox-2, cyclooxygenase-2; ERK, extracellular signal-regulated kinase; IL-6, interleukin-6; MAPK, mitogen-activated protein kinase; MMP, matrix metallopeptidase; NF-κB, nuclear factor-κB; PI3K, phosphatidylinositol-3 kinase; TGF, transforming growth factor; VEGF, vascular endothelial growth factor. Downward arrow ↓, decrease; Upward arrow ↑, increase.