Table 2.

Binding free energies of carbazole derivatives against hTopo I, hTopo II and actin.

Compounds	hTopo I	hTopo II	Actin
1	−7.22	−8.13	−7.52
2	−6.46	−7.17	−7.56
3	−8.62	−7.61	−7.42
4	−7.95	−8.75	−8.0
5	−6.30	−7.75	−6.88

The binding energies are calculated using the software Autodock 4.0.2 and expressed in Kcal/mol.