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CO suppresses the release of IL-1β through the inhibition of caspase-1 activation. Immunoblotting analysis of culture supernatants (Sup) and whole cell lysates (WCL), with results shown for LPS (100 ng/mL)-primed BMDMs pre-treated with CO or 50 μM YVAD (Y) at the indicated concentrations for 30 min followed by (A) poly(dA:dT) (1 μg/mL) transfection for 2 h, (B) nigericin (10 μM) treatment for 1 h, and flagellin (1 μg/mL) transfection for 3 h.
