Table 5.

Main severe toxicities in studies investigating adjuvant treatment after CRLM resection.

Reference	Severe Toxicities
Kanemitsu et al., 2021 [33]	AC: neutropenia: 50%, neuropathy: 10%, allergic reaction: 4%
Kokudo et al., 2021 [34]	Total: 12.2%, decreased Hb: 3.7%, diarrhea: 4.9%
Satake et al., 2021 [35]	Neutropenia: 29%
Nishioka et al., 2017 [38]	Oxaliplatin group: 50.9% UFT group: 6.8%
Kato et al., 2015 [39]	Neutropenia: 5%, fatigue: 6.7%
Kim et al., 2011 [44]	Neutropenia: 13.3%, anemia: 9.9%, thrombocytopenia: 11.6%, stomatitis: 8.3%, peripheral neuropathy: 3.3%
Alberts et al., 2010 [55]	HAI catheter/pump-related complications
Ychou et al., 2009 [46]	FOLFIRI: 47% (neutropenia 23%, diarrhea 14%), LV5-FU: 30% (neutropenia 7%, diarrhea 7%)
Portier et al., 2006 [48]	Diarrhea: 8.6%; hematologic, stomatitis, nausea: 7.4%; neuropathy: 2.47% (adjuvant chemotherapy arm)
Mackay et al., 2005 [49]	Neutropenia: 20.7%, diarrhea: 17.2%, vomiting: 13.8%
Gardini et al., 2004 [50]	Hyperpyrexia: 28,5%, oliguria: 14,2%
Kemeny et al., 2002 [56]	Increased liver enzymes: 30% (HAI arm)
Kemeny et al., 1999 [58]	Neutropenia: 21 vs. 18%, diarrhea: 14 vs. 29%, vomiting: 5 vs. 10%, bil > 3 mg/dL: 18% (HAI arm)
Lorenz et al., 1998 [60]	Stomatitis: 57.6 %, nausea: 55.4%, skin reaction: 26.9%, alopecia: 26.9%, pain: 24.9%, diarrhea: 23.6%
Kokudo et al., 1998 [61]	Unknown staging of complications