Table A1.

Risk of bias assessment of randomized clinical trials according to RoB2 tool.

Study	Randomization Process	Deviation from Intended Interventions	Missing Outcome Data	Measurement of Outcome	Selection of Reported Result	Overall
Kokudo et al., 2021 [34]	1.2 Y, 1.1 Y, 1.3 N LR	Part1: 2.1/2.2 Y, 2.3 PY, 2.4 PN SC Part2: 2.6Y LR	3.1 Y LR	4.1 N, 4.2 N, 4.3 Y, 4.4 PN LR	5.2/5.3 N 5.1 Y LR	SC
Kanemitsu et al., 2021 [33]	1.2 Y, 1.1 Y/PY, 1.3 N/PN LR	Part1: 2.1/2.2 Y, 2.3 PY, 2.4 PN SC Part2: 2.6Y LR	3.1 Y LR	4.1 N, 4.2 N, 4.3 Y, 4.4 PN LR	5.2/5.3 N 5.1 Y LR	SC
Kemeny et al., 2011 [43]	1.2 NI, 1.3 PN SC	Part1: 2.1/2.2 NI, 2.3 N LR Part2: 2.6 Y LR	3.1 Y LR	4.1 N, 4.2 N, 4.3 Y, 4.4 PN LR	5.2/5.3 N 5.1 Y LR	SC
Ychou et al., 2009 [46]	1.2 NI, 1.3 PN SC	Part1 : 2.1/2.2 Y, 2.3 PY, 2.4 PN SC Part2: 2.6N, 2.7 PN SC	3.1 Y LR	4.1 N, 4.2 N, 4.3 Y, 4.4 PN LR	5.2/5.3 N 5.1 Y LR	HR
Portier et al., 2006 [48]	1.2 NI, 1.3 PN SC	Part1: 2.1/2.2 Y, 2.3 PY, 2.4 PN SC Part2: 2.6Y LR	3.1 Y LR	4.1 PY HR	5.2/5.3 N 5.1 Y LR	HR
Kemeny et al., 2002 [56]	1.2 NI, 1.3 PN SC	Part1: 2.1/2.2 Y, 2.3 Y, 2.4 PN SC Part2: 2.6 N, 2.7 PY HR	3.1 Y LR	4.1 NI, 4.2 N, 4.3 Y, 4.4 PN LR	5.2/5.3 N 5.1 Y LR	HR
Tono et al., 2000 [57]	1.2 Y, 1.1 Y, 1.3 N LR	Part1 : 2.1/2.2 Y, 2.3 N LR Part2: 2.6 PY LR	3.1 Y LR	4.1 N, 4.2 N, 4.3 Y, 4.4 PN LR	5.2/5.3 N 5.1 Y LR	LR
Kemeny et al., 1999 [58]	1.2 NI, 1.3 PN SC	Part1: 2.1/2.2 Y, 2.3 Y, 2.4 NI, 2.5 NI HR Part2: 2.6 Y, 2.7 PY HR	3.1 Y LR	4.1 N, 4.2 N, 4.3 Y, 4.4 PN LR	5.2/5.3 N 5.1 Y LR	HR
Rudroff et al., 1998 [59] ¹	1.2 NI, 1.3 PN SC	Part1: 2.1/2.2 Y, 2.3 PN LR Part2: 2.6 PY LR	3.1 Y LR	4.1 NI, 4.2 Y HR	5.2/5.3 N 5.1 Y LR	HR
Lorenz et al., 1998 [60]	1.2 Y, 1.1 NI, 1.3 PN LR	Part1: 2.1/2.2 Y, 2.3 PY, 2.4 PN SC Part2 : 2.6Y LR	3.1 Y LR	4.1 N, 4.2 N, 4.3 Y, 4.4 PN LR	5.2/5.3 N 5.1 Y LR	SC

Abbreviations: LR: low risk; SC: some concern; HR: high risk. ¹ The risk of bias assessment for this study focuses only on the comparison between groups A and B.