Table 3.
Power of GMFM-66 and MDSC to detect differences in GMFM-66 score in samples of different group sizes with defined GMFM-66 score differences.
| Power of GMFM66-Score | ||||||||
|---|---|---|---|---|---|---|---|---|
| GMFM66-Score Difference of the Compared Groups | ||||||||
| Size of the Samples, n | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 |
| 30 | 0.0 | 0.5 | 2.0 | 3.9 | 20.2 | 68.1 | 94.8 | 99.1 |
| 40 | 0.1 | 1.8 | 5.5 | 20.5 | 71.3 | 97.9 | 98.8 | 100.0 |
| 50 | 0.6 | 4.4 | 12.8 | 58.8 | 96.7 | 99.9 | 100.0 | 100.0 |
| 75 | 3.6 | 16.1 | 77.1 | 99.4 | 99.9 | 100.0 | 100.0 | 100.0 |
| 100 | 10.9 | 60.9 | 99.7 | 100.0 | 100.0 | 100.0 | 100.0 | 100.0 |
| 150 | 53.3 | 99.6 | 100.0 | 100.0 | 100.0 | 100.0 | 100.0 | 100.0 |
| 200 | 89.8 | 100.0 | 100.0 | 100.0 | 100.0 | 100.0 | 100.0 | 100.0 |
| 250 | 99.8 | 100.0 | 100.0 | 100.0 | 100.0 | 100.0 | 100.0 | 100.0 |
| Power of Medical Device-Score | ||||||||
| GMFM66-Score difference of the compared groups | ||||||||
| Size of the samples, n | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 |
| 30 | 0.7 | 2.3 | 6.7 | 10.6 | 21.0 | 40.8 | 55.0 | 80.6 |
| 40 | 2.3 | 4.7 | 13.8 | 22.1 | 38.3 | 63.6 | 82.0 | 94.8 |
| 50 | 3.0 | 9.2 | 24.3 | 34.9 | 57.5 | 80.4 | 93.9 | 99.1 |
| 75 | 10.3 | 26.0 | 53.6 | 66.7 | 88.2 | 98.1 | 99.6 | 100.0 |
| 100 | 20.3 | 47.0 | 79.5 | 88.4 | 98.1 | 100.0 | 100.0 | 100.0 |
| 150 | 50.5 | 82.1 | 97.9 | 99.5 | 100.0 | 100.0 | 100.0 | 100.0 |
| 200 | 75.0 | 96.3 | 99.9 | 100.0 | 100.0 | 100.0 | 100.0 | 100.0 |
| 250 | 91.0 | 99.5 | 100.0 | 100.0 | 100.0 | 100.0 | 100.0 | 100.0 |
Bold is the smallest group size with which a difference could be shown in more than 80%. Of particular note, a maximum difference of 3 points was achieved in 89.8% using the GMFM-66 score with a group size of 200. Using the MDS, 250 patients are needed to achieve this for 91.0%.