Table 5.

CSF/plasma ratios in three patients before and after different dose infusions.

	CSF/Plasma Ratio before Infusion	CSF/Plasma Ratio after 1 h	CSF/Plasma Ratio after 8 h
Patient 1 (dose 7 mg/kg/day)	0.05	0.01	0.02
Patient 1 (dose 10 mg/kg/day)	0.38	0.06	0.19
Patient 2 (dose 10 mg/kg/day)	0.06	0.03	0.03
Patient 2 (dose 15 mg/kg/day)	0.16	0.05	0.07
Patient 3 (dose 8 mg/kg/day)	0.22	0.06	0.08