Table 6.

Microbiological success according to the different doses of micafungin, the identified minimum inhibitory concentration (MIC), and the AUC/MIC ratio.

	Target	AUC/MIC ≥ 3000
	Dose (mg/kg)	2	4	8	10
MIC (mg/L)	0.008	88.8%	97.3%	99.7%	99.9%
	0.016	56.3%	88.8%	97.3%	98.6%
	0.032	11.2%	56.3%	88.8%	92.9%
	0.064	0.3 %	11.2%	56.3%	70.7%
	0.125	0.0%	0.3%	11.2%	23.5%
	0.25	0.0%	0.0%	0.3%	1.3%
	0.5	0.0%	0.0%	0.0%	0.0%
	1	0.0%	0.0%	0.0%	0.0%
	Target	AUC/MIC ≥ 2000
	Dose (mg/kg)	2	4	8	10
MIC (mg/L)	0.008	94.9%	99.1%	99.9%	100.0%
	0.016	79.7%	94.9%	99.1%	99.5%
	0.032	34.2%	79.7%	94.9%	96.9%
	0.064	3.4%	34.2%	79.7%	87.0%
	0.125	0.0%	3.8%	35.9%	53.3%
	0.25	0.0%	0.0%	3.8%	9.9%
	0.5	0.0%	0.0%	0.0%	0.2%
	1	0.0%	0.0%	0.0%	0.0%
	Target	AUC/MIC ≥ 1000
	Dose (mg/kg)	2	4	8	10
MIC (mg/L)	0.008	99.1%	99.9%	100.0%	100.0%
	0.016	94.9%	99.1%	99.9%	100.0%
	0.032	79.7%	94.9%	99.1%	99.5%
	0.064	34.2%	79.7%	94.9%	96.9%
	0.125	3.8%	35.9%	79.7%	87.8%
	0.25	3.8%	3.8%	35.9%	53.3%
	0.5	0.0%	0.0%	3.8%	9.9%
	1	0.0%	0.0%	0.0%	0.0%