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. 2023 Mar 10;12(6):2173. doi: 10.3390/jcm12062173
HNSCC: head and neck squamous cell carcinoma;
CAR-T: chimeric antigen receptor T;
MHC: non-major histocompatibility complex;
scFv: single-chain variable fragment;
VL: variable light chain;
VH: variable heavy chain;
TRUCK: T cells redirected for universal cytokine killing;
IL: interleukin;
UniCAR-T: universal CAR-T;
CRS: cytokine release syndrome;
EGFR: epidermal growth factor receptor;
GBM: glioblastoma;
HER2: human epidermal growth factor receptor 2;
GD2: ganglioside D2;
FPA: fibroblast activation protein;
MUC1: mucin 1;
EpCAM: epithelial cell adhesion molecule;
NKG2DL: natural killer group 2 member D ligand;
LMP1: latent membrane protein;
TME: tumor microenvironment;
NIR: near infrared
aPDL1: anti-programmed death-ligand-1-blocking antibody;
PTT: photothermal therapy;
CXCR: C-X-C motif chemokine receptor;
HPSE: heparinase;
TanCAR-T: tandem CAR-T cells;
SUPRA: split, universal and programmable;
OVs: oncolytic viruses;
CAd: binary oncolytic adenovirus;
PD-L1: programmed cell death-ligand 1;
FHVH33: humanized heavy-chain variable domain;
synNotch: synthetic notch;
EphA2: ephrin type A receptor 2;
iCAR-T: inhibitory CAR-T;
iC9: caspase-9;
CID: chemical inducer of dimerization;
STAT3: signal transducer and activator of transcription 3.