HNSCC: |
head and neck squamous cell carcinoma; |
CAR-T: |
chimeric antigen receptor T; |
MHC: |
non-major histocompatibility complex; |
scFv: |
single-chain variable fragment; |
VL: |
variable light chain; |
VH: |
variable heavy chain; |
TRUCK: |
T cells redirected for universal cytokine killing; |
IL: |
interleukin; |
UniCAR-T: |
universal CAR-T; |
CRS: |
cytokine release syndrome; |
EGFR: |
epidermal growth factor receptor; |
GBM: |
glioblastoma; |
HER2: |
human epidermal growth factor receptor 2; |
GD2: |
ganglioside D2; |
FPA: |
fibroblast activation protein; |
MUC1: |
mucin 1; |
EpCAM: |
epithelial cell adhesion molecule; |
NKG2DL: |
natural killer group 2 member D ligand; |
LMP1: |
latent membrane protein; |
TME: |
tumor microenvironment; |
NIR: |
near infrared |
aPDL1: |
anti-programmed death-ligand-1-blocking antibody; |
PTT: |
photothermal therapy; |
CXCR: |
C-X-C motif chemokine receptor; |
HPSE: |
heparinase; |
TanCAR-T: |
tandem CAR-T cells; |
SUPRA: |
split, universal and programmable; |
OVs: |
oncolytic viruses; |
CAd: |
binary oncolytic adenovirus; |
PD-L1: |
programmed cell death-ligand 1; |
FHVH33: |
humanized heavy-chain variable domain; |
synNotch: |
synthetic notch; |
EphA2: |
ephrin type A receptor 2; |
iCAR-T: |
inhibitory CAR-T; |
iC9: |
caspase-9; |
CID: |
chemical inducer of dimerization; |
STAT3: |
signal transducer and activator of transcription 3. |