Figure 3.

Gram-scale synthesis of a protected fondaparinux pentasaccharide using a dual-mode automated solution-phase glycan synthesizer. A library of oligosaccharides covering various glycoforms and glycosidic linkages assembles rapidly, either in a general promoter-activation mode or light-induced-activation mode. The synthesis used thioglycoside d-glucuronic acid containing disaccharide with 3,6-di-O-acetyl groups for the α-directing glycosylation and l-iduronic-acid-containing disaccharide as building blocks. All compounds are readily obtained from commercially available monosaccharide or disaccharide intermediates. Reproduced with permission form ref (31). Copyright 2022, Springer Nature.